The Oscar winner picked up the rights for Cheryl Strayed's Wild four months before the novel was published, and now her foresight appears to have paid off - Winfrey has picked the tome for her revived book club.
Witherspoon and her Pacific Standard production partner Bruna Papandrea are planning to turn the story into a new movie, with The Kids Are All Right's Lisa Cholodenko as director.
Thrilled Papandrea says, "It was the first thing we picked up together," and Witherspoon tells The Hollywood Reporter, "Wild is a magical and evocative book about losing everything - family, money, your mother, your partner - and finding your true spirit alone in the woods."
Oprah's Book Club became a big part of the TV queen's former daytime talk show. It ended when Winfrey walked away from the show in 2010.
The recently married Oscar winner and mum of two has been acting for over two decades but Witherspoon confesses she's now eager to step behind the camera.
The blonde beauty is teaming up with gal pal and Milk producer Bruna Papandrea to create a new firm, which will empower women and ensure they have an opportunity to pursue their dreams.
The Walk the Line star tells Reuters, "We will be producing some films with a very clear female voice.
"I’ve been acting since I was 14, and I know every aspect of filmmaking at this point. I think it’s important for women who have attained a certain amount of success in this business to give back to other female writers and filmmakers and try and help facilitate their dreams."
Witherspoon launched her first production company, Type A Films, in 2000.