The couple has been dogged by split rumours since the beginning of the year (12), with gossips indicating the pair had grown apart and speculation continued to grow as both Depp and the singer played coy about the status of their relationship.
But now the parents of two have finally called it quits.
A statement released to Entertainment Tonight by the Pirates of the Caribbean star's publicist reads, "(They) have amicably separated. Please respect their privacy and, more importantly, the privacy of their children."
Depp and Paradis began dating in 1998 but never married. They have two children, Lily-Rose, 13, and Jack, 10.
The Pirates of the Caribbean star began dating singer Paradis in 1998 and they have set up home in the south of France with their two children, Lily-Rose, 12, and Jack, 10.
Earlier this year (12), gossips suggested the couple had begun to live separate lives due to growing tension about the actor's booming career, and speculation about a separation continued to swirl as Depp and Paradis played coy about the status of their relationship in media interviews.
The lovers of 14 years have not been photographed in public together for some time, and French star Paradis left Depp to walk the red carpet solo on Wednesday (09May12) for the London premiere of his new movie Dark Shadows.
But Depp, 48, has now spoken out to quell the claims once and for all, telling Britain's The Sun newspaper, "No matter what I say about this, people believe the opposite. I can't say enough about it (the relationship) not being over. The rumours are not true. They are absolutely not true."
Reports that the Pirates of the Caribbean star and the French singer/actress, who share two children, have parted ways mounted earlier this month (Jan12) amid rumours suggesting they have been living separate lives.
The couple has refused to directly address the gossip, but Paradis braved the press on Monday night (23Jan12) to walk the red carpet solo at the premiere of her new film Cafe de Flore in Paris, France.
And during a French radio interview this week (begs23Jan12), she admitted her 15 year relationship has been plagued by unsubstantiated rumours.
Speaking on the Europe 1 station, Paradis says, "You know, when I eat three peas, I'm pregnant. When I visit a city, I'm buying a house.
"In the winter I separate, in the summer I marry. It's been 15 years since I've been getting married every year. In addition I have to answer all these rumours!"
Matt Damon has topped a new poll to be named the Sexiest Man Alive.
The Bourne Ultimatum star, 37, beat Grey's Anatomy hunk Patrick Dempsey--who is nicknamed Doctor McDreamy on the hit medical series--and Amityville Horror actor Ryan Reynolds to pole position on the annual People magazine hotlist.
The title will be a welcome accolade for Damon: He recently revealed it has been his longtime ambition to beat pal George Clooney--a frequent entrant in such surveys--to the coveted No. 1 spot.
But the married Damon, who became a first-time father earlier this year, remains coy about his win.
He tells People, "You've given an aging suburban dad the ego boost of a lifetime."
The magazine cites Damon's "irresistible sense of humor," "rock-solid family man" and "heart-melting humility" for landing him the title.
The top 10 Sexiest Men are as follows:
1. Matt Damon
2. Patrick Dempsey
3. Ryan Reynolds
4. Brad Pitt
5. James McAvoy
6. Johnny Depp
7. Dave Annable
8. Will Smith
9. Javier Bardem
10. Shemar Moore
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