Fassbender pulled in a haul of nominations for his portrayal of a sex addict in the gritty 2011 drama, including nods for Best Actor at the Golden Globes and the British Academy of Film and Television Arts awards (BAFTA).
His performance is now in contention for a top acting prize at the 25th EFAs, where he faces competition from Mads Mikkelsen (Jagten), Gary Oldman (Tinker Tailor Soldier Spy), Jean-Louis Trintignant (Amour), and The Intouchables co-stars Francois Cluzet and Omar Sy.
Shame is also up for another four trophies, including European Film, European Director for Steve McQueen, European Cinematographer Award and European Editor.
Alongside Shame, the other nominees for European Film 2012 are Amour, Barbara, Jagten, Cesare Deve Morire and The Intouchables.
Kate Winslet is included in the Best Actress category for her turn in Roman Polanski's Carnage, and is up against Margarethe Tiesel (Paradies: Liebe), Emmanuelle Riva (Amour), Nina Hoss (Barbara), and Emilie Dequenne (A Perdre La Raison).
Dame Helen Mirren will be presented with a lifetime achievement award at the ceremony, which will take place in Malta on 1 December (12).
As well as the event's coveted Golden Bear, Asghar Farhadi's controversial film also picked up Silver Bears for Best Male and Female Actor/Actress.
German moviemaker Ulrich Koehler took the Best Director Silver Bear Sleeping Sickness, while Hungary's Bela Tarr landed the Jury Grand Prize for The Turin Horse.
Italian actress Isabella Rossellini presided over the Berlin competition jury, which included German actress Nina Hoss and costume designer Sandy Powell.
Jeff Bridges, Josh Brolin, Hailee Steinfeld, Jeremy Irons, Colin Firth, Helena Bonham-Carter and Ralph Fiennes were among the international stars who graced the 11-day festival in Berlin.
The full list of leading Berlinale winners is:
Golden Bear for Best Film
Nader and Simin, A Separation
Silver Bear, The Jury Grand Prix
The Turin Horse
Silver Bear, Best Director
Ulrich Kohler for Sleeping Sickness
Silver Bear, Best Actress
for ensemble in Nader & Simin, A Separation
Silver Bear, Best Actor
for ensemble in Nader & Simin, A Separation
Silver Bear, Outstanding Artistic Achievement
Wojciech Staron for The Prize
Barbara Enriquez for The Prize
Silver Bear, Best Script
Joshua Marston and Andamion Murataj for The Forgiveness Of Blood
Alfred Bauer Prize
If Not Us, Who?
The man behind acclaimed films like Downfall and The Baader Meinhof Complex passed away after suffering a heart attack on Monday (24Jan11) at the age of 61.
Many consider Eichinger to be Germany's most successful moviemaker, with other credits including The Name of the Rose, the Resident Evil films and The Fantastic Four.
Berlin Festival director Dieter Kosslick has paid tribute to Eichinger, calling him a "visionary producer and passionate cineaste".
And he reveals festival organisers will honour him at the upcoming event with a screening of his 1996 drama A Girl Called Rosemarie, one of the rare films he both produced and directed.
The film features a breakout performance by actress Nina Hoss, who is a member of this year's (11) international jury, headed by Isabella Rossellini. The annual festival runs from 10 to 20 February (11).
Eichinger is survived by his wife Katja and daughter Nina, a well-known German TV personality.
The Chinese New Year got off to a spectacular start in Berlin when director Wang Quan'an was awarded the film festival's top honor, the Golden Bear, for Tuya's Marriage.
The Chinese movie, which is set in Inner Mongolia, was announced on Saturday.
A thrilled Wang said, "A very beautiful dream has become reality for me here.
"Perhaps this is the last glance at the herds people of the region. Ultimately they are going to disappear into the cities. I think that it is important, particularly in this time when the economy is booming, to ponder and reflect on what we're losing."
U.S.-born Israeli Joseph Cedar took Best Director for his war drama Beaufort at the film festival, while Best Actor and Actress prizes went to Julio Chavez (The Other) and Nina Hoss (Yella), respectively.
Actor-turned-moviemaker Robert De Niro also had a share of the accolades--The Good Shepherd, his drama on the origins of the CIA, won for Outstanding Artistic Contribution.
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