The Welsh actress, who won an Oscar for her role in Chicago, will play the villainous, ultra-conservative Mayor's wife in the film adaptation of the Broadway show, which includes Russell Brand, Tom Cruise, Mary J. Blige, Alec Baldwin and Julianne Hough among its cast.
Zeta-Jones' role was created specifically for the film, according to EW.com.
Her casting comes a week after revelations she is struggling from Bipolar II disorder, which recently prompted her to check into a treatment centre.
Director Adam Shankman can't wait to work with the star, insisting she's too professional to allow her condition to interfere with her work.
He tells EW.com, "I think she's seeing this as a wonderful homecoming for her. It (movie musical) puts her in an incredible comfort zone. The truth of the matter is, I'm working with a lot of the same people that she worked with on Chicago, so she's going to be returning to a real family situation.
"There's a group of people that are there literally just to kind of be with her and support her. And, having rehearsed with her, she's so happy and at home in the rehearsal room, and when you put that quarter in her and turn her on to sing and dance, it's just magic."
The British funnyman was trying to schedule the role of Lonny around his summer plans with wife Katy Perry and now it appears he's sorted out the logistics.
He'll join Tom Cruise, Julianne Hough, Alec Baldwin and Mary J. Blige among the supporting cast of the film.
Little-known Mexican actor Diego Boneta was announced as the star of the project last week (ends08Apr11).
The film will be adapted from the hit Broadway musical of the same name.
The star is preparing for his role as bad boy rocker Stacee Jaxx, and he's very serious about coming across as a bona-fide rock god on the big screen, according to director Adam Shankman.
The moviemaker tells TheWrap.com, "He's been studying with Axl Rose's voice teacher, like, five hours a day. The prognosis is more than excellent.
"The voice lesson where he opened up and suddenly let loose... was really great.
Julianne Hough, Alec Baldwin and Mary J. Blige will join Cruise in the film.
The little known TV star reportedly wowed producers and director Adam Shankman in auditions and he has been added to the cast alongside Tom Cruise, Julianne Hough and Mary J. Blige, according to Variety.
With the main casting complete, the film will go before the cameras in Florida on 19 May (11).
The film is an adaptation of hit stageshow Rock of Ages, which uses the music of Journey, Bon Jovi and Joan Jett, among others, to tell the story of a couple who meet and fall in love at a Sunset Strip club in Los Angeles.
Meanwhile, Cruise's wife Katie Holmes reveals her husband is deadly serious about his first big screen song-and-dance role: "He's so excited to do it... He's thrilled."
"It’s, like, 'I gotta show him I’ve got some balls. I’m not gonna sit there and not say anything. I gotta interact. He’s amazing." Julianne Hough on working with Tom Cruise in new movie musical Rock of Ages.
The big screen adaptation of the Broadway show already boasts a star-studded cast, including Tom Cruise, Alec Baldwin and Mary J. Blige, and Shankman is looking for an acting newcomer to fill the role of Drew Boley.
Movie studio bosses are calling on wannabe male actors between the ages of 18 and 25 "with a real rock 'n' roll singing voice" to attend auditions in Los Angeles on 26 March (11), according to The Hollywood Reporter.
Burlesque star Hough joined the movie line-up as Sherrie earlier this month (Mar11). Filming will begin in Florida in May (11).
ALEC BALDWIN has joined the star-studded ROCK OF AGES cast. The movie star will join Tom Cruise, Julianne Hough and Mary J. Blige in the film adaptation of the hit stage musical, which features the music of Journey and Bon Jovi.
The country singer and former Dancing with the Stars champion is in final negotiations to star as Sherrie in the film.
Cruise will play Staci Jaxx in the movie, which will begin shooting in Florida in May (11), according to Daily Variety.
The Mission: Impossible star will play Stacee Jaxx in the film, and belt out Bon Jovi's Wanted Dead or Alive.
Matt Weaver, who co-created Rock of Ages, is thrilled with the casting: "He's got an awesome voice! He's got an awesome attitude.
"He's embracing it, he's getting into character, he's doing his research. He's ready to go back to 1986!"
Julianne Hough, Alec Baldwin, Anne Hathaway and Russell Brand are also reportedly in talks to join the cast.
Hough was among the stars who attended the opening night of the hit musical's run in Los Angeles on Tuesday (15Feb11). Zac Efron, Malin Akerman, Shannon Elizabeth, Carmen Electra and Mena Suvari were among the audience.
Country music star Hough has been dating Seacrest since earlier this year (10) tabloids are keen to marry the hot new couple off.
Recent reports suggested Seacrest proposed to the Burlesque star during a romantic trip to Paris over Thanksgiving (25Nov10). The couple dismissed the speculation - but now the media has hinted the pair will ring in 2011 with big news and a ring.
Seacrest, who is hosting annual New Year's Eve (31Dec10) TV festivities in New York, appeared on U.S. breakfast programme Good Morning America on Thursday (30Dec10) to set the record straight - insisting he's not ready to take their relationship to the next level - yet.
He said, "I'm not engaged - but I'm very happy."