Fresh-faced and sparkly eyed when she was plucked from the audience to dance with Bruce Springsteen in his classic "Dancing in the Dark" video, this former fashion model has spent most of her career playing variations on that same pretty, all-American girl. Cox was Michael J. Fox's love interest on the last few seasons of Family Ties and although she subsequently appeared in a smattering of films, she became a small-screen icon as a sweet, if uptight, neat freak on the beloved, decade-long sitcom Friends. While she was the only member of the ensemble never to earn an Emmy nod, Cox landed on plenty of magazine hot lists and launched a moderately successful film career, highlighted by her bitchy, against-type turn in the blockbuster Scream trilogy. Although her previous high-profile relationship with Michael Keaton ended in heartbreak, she married her significantly younger Scream costar David Arquette, and the couple remained in the spotlight as they publicly battled fertility issues. In 2004, Friends came to a close and Cox opened up a new chapter in her life as a mother. But after a few years of keeping a relatively low profile, she returned to series television as a tabloid editor in Dirt, which she produced with her husband.