Beckinsale will be handed the prestigious Lacoste Spotlight Award for her style choices, while movie legend Eastwood will receive the Distinguished Collaborator Award alongside his longtime on-set designer Deborah Hopper.
The pair has worked on 16 films together, including Mystic River and Million Dollar Baby.
Marlene Stewart and Lou Eyrich will also be honoured at the CDGAs for their contributions to the entertainment industry.
Stewart, who once helped style Madonna for her music videos, has worked on movies like 21 Grams and JFK. and the upcoming Hansel and Gretel: Witch Hunters. Eyrich is best known for creating the look of the characters on TV hit Glee.