Takamine passed away at a Tokuo hospital on Tuesday (28Dec10), reports Kyodo News.
The actress made her film debut at the age of five in 1929 silent film Haha (Mother) and rose to fame as Japan's answer to Shirley Temple.
She gained stardom with 1938's Tsuzurikata Kyoshitsu (Writing Lessons) and went on to appear in a string of major hits in the 1950s, including Niju-shi no Hitomi (Twenty-four Eyes) in 1954, Ukigumo (Floating Clouds) in 1955 and Yorokobi mo Kanashimi mo Ikutoshitsuki (The Lighthouse) in 1957.
Her fame continued after she retired from acting in 1979, when she embarked on a second career as an award-winning essayist.
She is survived by her husband, director and writer Zenzo Matsuyama.