After picking up the Crystal Award at the World Economic Forum in Switzerland, the Oscar winner will be feted for the work she does to eradicate AIDS through her Charlize Theron Africa Outreach Project.
The actress will be awarded the Honorary Chair of this year's Cinema for Peace Gala at the Waldorf Astoria Hotel, where she'll be awarded the Cinema for Peace Honorary Award.
Gala founder Jaka Bizilj says, "As a South African, Charlize Theron cares deeply about the human suffering of those infected, their families and friends due to HIV and AIDS. Every day thousands of people die of this disease. Charlize Theron's Africa Outreach Project contributes tremendously in the concerned areas, helping to educate children and minors about HIV and AIDS as well as to support affected persons."
Also up for major honours at the event are films by Oscar-nominated directors Michael Haneke (Amour), Ang Lee (Life of Pi), Steven Spielberg (Lincoln) and Benh Zeitlin (Beasts of the Southern Wild), who are all nominated in the Most Valuable Movie of the Year category at the gala, alongside Ben Affleck, Kathryn Bigelow, Nicholas Jarecki, Juan Antonio Bayona, Jacques Audiard and Kim Nguyen.
The star has received plenty of acclaim during the ongoing Hollywood awards season for his thriller Argo, but it was his work with his Eastern Congo Initiative that was recognised by the Cinema for Peace Foundation at the Gala for Humanity in Beverly Hills.
Affleck picked up the Humanitarian Award and was hailed for demonstrating the "foresight, courage and leadership" needed to "take a stand against extreme injustice, intolerance and inequalities".
Jaka Bizilj, founder of Cinema for Peace, says, "The Eastern Congo Initiative is the first U.S.-based advocacy and grant-making initiative wholly focused on working with and for the people of Eastern Congo. The Cinema for Peace Foundation is pleased to honour Ben Affleck for his courageous efforts to raise awareness about this terrible catastrophe and his brave stand against the injustices experienced by the Congolese. We are proud to support their work by providing desperately needed financial resources."
The event attracted an A-list guest list, including pregnant star Kristen Bell and her funnyman partner Dax Shepard, as well as British actress Thandie Newton and her director husband Ol Parker.