The actress compiled the hit list of songs that will appear during her new roller derby film Whip It - and insisted her former lover's group Little Joy should be included.
She tells Billboard.com, "What was so exciting was to finally get to make a film that I could make an ultimate mixtape for and put the two together.
"It was sort of waiting my whole life, incubating, and I finally got to make them together... I'm really excited to bring that music to people."
The soundtrack also features Dolly Parton's Jolene, the Ramones' Sheena is a Punk Rocker and songs by Peaches and Jens Lekman.
Barrymore also commissioned new tracks by singer/songwriter Landon Pigg, who also appears in the film, Har Mar Superstar and Squeak E. Clean & Desert Eagles.
She adds, "Most of the people who are on this soundtrack are friends, people we took the time to go to personally and ask them if they would associate themselves with the movie, or people that we discovered that we can't wait to get to know. It's really interesting to have such personal relationships with everyone."