She first appeared on screen in the video to French singer-songwriter Raphael's 2005 single, "Ne Parton Pas Faches."
"I don’t mind being shy. Sometimes I’m terribly shy. Sometimes I’m not shy. I’m fine with it. I know I’m like that and that I will always be like that." Seydoux quoted in The Scotsman, Oct. 28, 2012
"I really love doing films in America, because I love to speak English. But I think there's something very entertaining about American films. But I also like the intimacy of French films." Seydoux quoted in Interview Magazine, October 2012.
Seydoux became the face of the Prada Candy fragrance in 2012 and starred alongside Michael Pitt in the fall 2013 ad campaign for Rag & Bone.