The blonde beauty wed TV star Indra in 2004, just before Faris' career took off - and she admits her blossoming list of film credits tore them apart.
She tells Marie Claire, "That kind of destroyed my marriage. The divide became too great."
Faris filed for divorce in 2007 and became a Los Angeles party girl.
She adds, "I was like, 'F**k it, I've got nothing to lose, nobody to support.' I wore the same Garfield shirt and jeans for three weeks. I had a running joke with my friend: 'I hope somebody roofies (date rape drug) me tonight!' I didn't care what people thought."
But the wild times were short-lived - Faris wed actor Chris Pratt in 2009.
The Scary Movie star has been married twice, to Ben Indra between 2004 and 2008 and her current husband Chris Pratt, who she exchanged vows with in 2009.
Faris has now admitted she is stricken by insecurities in her love life, telling reporters at a screening of her new movie What's Your Number?, "I'm at five. Don't you think five is kind of low? I'm 34!... I'm not a very good lover. I'm so nervous about my sexuality."
The Scary Movie star wed Ben Indra in 2004 after they met on the set of movie Lovers Lane, but she filed for divorce in April 2007.
The actress admits the marriage break-up hit her hard - and she tried to compensate with a wild, party lifestyle.
She says, "I tend to be a serial monogamist. But the next thing you know, I'm single and living in an apartment full of potato chips, mustard and tons of beer. I wore this grubby Garfield t-shirt and these baggy jeans all the time.
"Personal hygiene? Nah. I would talk to my cat, I was drunk all the time. I would go to bars alone. I would talk to guys and be like, 'Sooo, what's your story? You wanna go out?' If they turned me down, I'd be like, 'So, what's your friend like?' It was a very selfish time in my life but also strangely liberating. I felt weirdly empowered."
Faris later remarried, exchanging vows with actor Chris Pratt earlier this year (Jul09).
Anna Faris and actor Chris Pratt are enjoying a Hawaiian honeymoon, after marrying on the island over the weekend.
The couple, who got engaged late last year, exchanged vows on Saturday and have kick-started married life in Maui.
Faris hinted that the pair would run off to wed last month, revealing plans to "slip off and elope" with her then-fiancé to avoid the pressure of a large family gathering.
Pratt confirms to Radaronline.com, "I'm a very happy guy. We're in Hawaii having a wonderful time."
This is the second marriage for the House Bunny star, who was previously wed to actor Ben Indra.
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