The Harry Potter star was honoured with the PPG Award for Best Performance in a British Feature Film trophy for his role in the new movie, which sees Rhys Ifans portray notorious drug smuggler Howard Marks.
The festival jury, which included Sir Patrick Stewart, director Mike Hodges and actress Britt Ekland, called Thewlis' performance as Irish Republican Army activist Jim McCann "energetic and electrifying".
Thewlis said, "This is a thrill and totally unexpected, and made all the more special by being honoured by one of my favourite cities in the world."
The Best New British Feature Film prize went to Skeletons, which features Thewlis' Harry Potter co-star Jason Isaacs, while America Ferrera's The Dry Land was named Best International Feature.
Robert Duvall's dark comedy Get Low took the 2010 Standard Life Audience Award and Gareth Edwards won the Moet New Directors Award for Monsters. The Best Feature Documentary Award went to The Oath.
Oscar-winning actress Tilda Swinton was on hand to help present the awards in her role as festival patron.
David Schwimmer will direct Clive Owen and Catherine Keener in Trust, the trades report.
The dark drama is about the damaging effects an online sexual predator has on a family. Millennium Films will produce and finance.
Schwimmer wrote the story for the drama with Andy Bellin on the script.
Owen and Keener will play the parents of a 14-year-old girl who discover she has been victimized by an adult who gained her trust posing as a teenager in a chat room. Liana Liberato will play the daughter.
Avi Lerner will produce with Heidi Jo Markel and Bob Greenhut. Executive producers are Danny Dimbort, Trevor Short, Boaz Davidson, Schwimmer and Tom Hodges.
This is Schwimmer's second feature as director following 2007's Run, Fatboy, Run.
Shooting begins Nov. 9 in Michigan.
Nu Image will distribute the film worldwide.
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It might have been early in the morning, but that didn't stop everyone from Dido to Moby to Evanescence's Amy Lee from showing up at the announcement of the 46th annual Grammy Award nominations this morning at the Beverly Hilton Hotel in Beverly Hills, Calif.
OutKast, Jay-Z, Beyoncé, and the Neptunes' Pharrell Williams are tied for the lead with six nominations apiece. Missy Elliott, 50 Cent, Eminem, the Neptunes' Chad Hugo, Justin Timberlake, Ricky Skaggs, Evanescence, Luther Vandross and the late Warren Zevon are close behind with five noms each.
The four big categories--album of the year, record of the year, song of the year and best new artist--reflect the dominance of rap, hip-hop and R&B artists in mainstream music as well as the renewed popularity of rock music.
Up for album of the year are Missy Elliott's Under Construction, Timberlake's Justified, Evanescence's Fallen, the White Stripes' Elephant and OutKast's Speakerboxxx/The Love Below.
Hip-hop duo's OutKast's single "Hey Ya!" will go head-to-head for record of the year against Black Eyed Peas' "Where is the Love?," Beyoncé and Jay-Z's "Crazy in Love," Eminem's "Lose Yourself" and Coldplay's "Clocks."
For song of the year, which goes to the songwriter as opposed to the recording artist, nominees are Linda Perry for Christina Aguilera's "Beautiful," Eminem and Luis Resto for Eminem's "Lose Yourself," Richard Marx and Luther Vandross for Vandross' "Dance With My Father," Avril Lavigne and the Matrix for Lavigne's "I'm With You" and the late Warren Zevon and Jorge Calderon for Zevon's "Keep Me in Your Heart."
Sean Paul, 50 Cent, Evanescence, Fountains of Wayne and Heather Headley will compete for the best new artist award.
The Grammy Awards will be held on Sunday, February 8 at the Staples Center in Los Angeles and will be telecast on CBS from 8-11:30 p.m. (EST/PST).
Here is a partial list of nominations (a full list of nominees is posted on Grammy.com):
Album of the Year
Under Construction, Missy Elliott
Speakerboxxx/The Love Below, Outkast
Justified, Justin Timberlake
Elephant, The White Stripes
Record of the Year
"Crazy In Love," Beyoncé Featuring Jay-Z
"Where Is The Love?," Black Eyed Peas featuring Justin Timberlake
"Lose Yourself," Eminem
"Hey Ya," Outkast
Best New Artist
Fountains Of Wayne
Song of the Year
Linda Perry for "Beautiful" (performed by Christina Aguilera)
Richard Marx and Luther Vandross for "Dance With My Father"
Avril Lavigne and The Matrix (Lauren Christy, Graham Edwards and Scott Spock) for "I'm With You"
Jorge Calderón and Warren Zevon for "Keep Me In Your Heart"
Jeff Bass, Marshall Mathers (aka Eminem) and Luis Resto for "Lose Yourself"
Best Rap Song (NEW!)
Calvin Broadus (aka Snoop Dogg), Chad Hugo and Pharrell Williams for "Beautiful" (performed by Snoop Dogg Featuring Williams and Uncle Charlie Wilson)
Shawn Carter (aka Jay-Z), Chad Hugo and Pharrell Williams for "Excuse Me Miss" (performed by Jay-Z Featuring Williams)
Mike Elizondo, Curtis Jackson (aka 50 Cent) and A. Young for "In Da Club" (performed by 50 Cent)
Jeff Bass, Marshall Mathers and Luis Resto for "Lose Yourself" (performed by Eminem)
Missy Elliott and Tim Mosley for "Work It" (performed by Elliott)
Best Rap Album
Missy Elliott, Under Construction
50 Cent, Get Rich Or Die Tryin'
Jay-Z, The Blueprint2 - The Gift & The Curse
Outkast, Speakerboxxx/The Love Below
Best R&B Album
Erykah Badu, Worldwide Underground
Blu Cantrell, Bittersweet
Aretha Franklin, So Damn Happy
Isley Brothers Featuring Ronald Isley aka Mr. Biggs, Body Kiss
Luther Vandross, Dance With My Father
Best Contemporary R&B Album
Ashanti, Chapter II
Beyoncé, Dangerously In Love
Mary J. Blige, Love and Life
Anthony Hamilton, Comin' From Where I'm From
R. Kelly, Chocolate Factory
Best Rock Album
Foo Fighters, One By One
matchbox twenty, More Than You Think You Are
Nickelback, The Long Road
Best Rock Song
Evanescence, "Bring Me To Life" (David Hodges, Amy Lee and Ben Moody)
Train, "Calling All Angels" (Charlie Colin, Pat Monahan, Jimmy Stafford and Scott Underwood)
Bruce Springsteen and Warren Zevon, "Disorder In The House" (Jorge Calderón and Warren Zevon)
The White Stripes, "Seven Nation Army" (Jack White)
Nickelback, "Someday" (Chad Kroeger, Mike Kroeger, Ryan Peake and Ryan Vikedal)
Best Rock Performance By A Duo Or Group With Vocal
The White Stripes
Best Female Pop Vocal Performance
Christina Aguilera, "Beautiful"
Kelly Clarkson, "Miss Independent"
Dido, "White Flag"
Avril Lavigne, "I'm With You"
Sarah McLachlan, "Fallen"
Best Pop Collaboration With Vocals
Lil' Kim and Christina Aguilera, "Can't Hold Us Down"
Tony Bennett and k.d. lang for "La Vie En Rose"
Pink and William Orbit for "Feel Good Time"
Bob Dylan and Mavis Staples for "Gonna Change My Way Of Thinking"
Sting and Mary J. Blige for "Whenever I Say Your Name"
Best Pop Vocal Album
Christina Aguilera, Stripped
George Harrison, Brainwashed
Annie Lennox, Bare
Michael McDonald, Motown
Justin Timberlake, Justified
Best Pop Male Vocal Performance
George Harrison, "Any Road"
Michael McDonald, "Ain't No Mountain High Enough"
Sting, "Send Your Love"
Justin Timberlake, "Cry Me A River"
Warren Zevon, "Keep Me In Your Heart"
Best Pop Instrumental Performance
Ry Cooder and Manuel Galbán for "Patricia"
Dave Koz, "Honey-Dipped"
Randy Newman, "Seabiscuit"
The Brian Setzer Orchestra, "The Nutcracker Suite"
Best Traditional Pop Vocal Album
Bette Midler Sings, Bette Midler
Rosemary Clooney Songbook, Rosemary Clooney
The A Wonderful World, Tony Bennett and k.d. lang
As Time Goes By…The Great American Songbook: Volume II, Rod Stewart
The Movie Album, Barbra Streisand
Best Spoken Word Album For Children
Charlie And The Chocolate Factory, Eric Idle
Harry Potter And The Order of the Phoenix, Jim Dale
Prokofiev: Peter And The Wolf/Beintus: Wolf Tracks, Bill Clinton, Mikhail Gorbachev and Sophia Loren
Tell Me A Scary Story, Carl Reiner
Winnie-The-Pooh, Jim Broadbent
Best Spoken Word Album
Fear Itself, Don Cheadle
Lies And The Lying Liars Who Tell Them: A Fair And Balanced Look At The Right, Al Franken
Living History, Hillary Rodham Clinton
Nikki Giovanni Poetry Collection, Nikki Giovanni
When You Ride Alone You Ride With Bin Laden, Bill Maher
Best Female Country Vocal Performance
Patty Loveless, On Your Way Home
Martina McBride, This One's For The Girls
Dolly Parton, I'm Gone
Shania Twain, Forever And For Always
Best Country Collaboration With Vocals
Willie Nelson and Norah Jones, Wurlitzer Prize (I Don't Want To Get Over You)
Willie Nelson and Toby Keith, Beer For My Horses
June Carter Cash and Johnny Cash, Temptation
Alan Jackson and Jimmy Buffet, It's Five O'Clock Somewhere
James Taylor and Alison Krauss, How's The World Treating You
Best Country Album
Faith Hill, Cry
Lyle Lovett, My Baby Don't Tolerate
Willie Nelson and Ray Price, Run That One By Me One More Time
Willie Nelson, Live And Kickin'
Shania Twain, Up!
Compilation, Livin', Lovin', Losin' - Songs of the Louvin Brothers