The veteran actress, best known for playing Cary Grant's onscreen fiancee in the 1957 movie classic, passed away at her home in Los Angeles on Tuesday (14Dec10) after suffering complications from a broken hip.
Her daughter Megan Lee confirmed the sad news to the Los Angeles Times.
Patterson began her career on the New York stage, notably appearing in a 1952 production of The Seven Year Itch on Broadway and scoring her first movie role a year later (53) in Taxi.
She remains best remembered for her role in An Affair to Remember, but gained legions of sci-fi fans when she appeared in 1980s TV series V, which was brought back to life for a new generation in 2009.
She also enjoyed roles in 1978's The Buddy Holly Story, as well as TV classics including Ironside, The Dukes of Hazzard and St. Elsewhere.