The actor will join William H. Macy, Fergie, Steve Coogan and Wayans brothers Damon and Marlon in Fox’s CGI/live-action movie adaptation of the 55-year-old comic, according to The Hollywood Reporter.
It won't be the first time Wilson's voice has been the star of a movie - he played Lightning McQueen in hit 2006 animated movie Cars and he portrays Coach Skip in pal Wes Anderson's upcoming animated tale Fantastic Mr. Fox.
The plasterer was the sole British applicant for the 1988 Winter Olympics ski-jumping competition and became the first competitor to represent Great Britain in the sport.
He became a national treasure despite his lack of success - finishing last in both of his events.
In 2007, Coogan was signed up to tackle the role of Edwards in a film depicting the comical athlete's Olympic journey.
But British newspaper the Sunday Mirror reports Grint will now take over from the Night At the Museum star.
The movie, directed by Declan Lowney, is scheduled to go into production later this year (09).
The actor/comedian was a big fan of the cult show in the days before the VCR and he had to memorise skits and sketches so he could reenact them for family friends.
The Tropic Thunder star explains, "You couldn't replay it... My mum might be talking to a friend and she'd say, 'Did you see that...? Steve, do it, do what was on the show last night.'
"So I would just be a video recorder; I'd just try and replicate what I had seen."
And he became a Monty Python perfectionist: "I'd get angry if I saw people trying to describe what was in the show, and getting it wrong."
Wilson was hospitalised two years ago (07) when he was found at his home in Santa Monica, Los Angeles after allegedly downing pills and slashing his wrists.
Following the incident Love, who previously dated Coogan, blamed the comedian for Wilson's downfall, saying at the time, "I was just out of rehab, and he was right there with the drugs. I tried to warn Owen. I tried to warn his friends... I hope from the bottom of my heart that Owen stays the hell away from that guy."
Coogan, who starred in Night at the Museum and Around the World in 80 Days alongside Wilson, strongly denied the accusation, branding it "unfounded, unhelpful and hurtful".
And the comic has now blasted reports his career and friendship with the Hollywood actor have deteriorated as a result of Love's claims.
He says, "It was a complete fabrication put out about by someone who had a different agenda. In America they realised it was b******s as soon as they established that it was spread by someone who was trying to throw a grenade in my path. The industry made it very clear to me that they knew, so thankfully it had no effect on my career or my friendship with Owen.
"Yes, Owen did have a bit of a personal wobble between the first Night At The Museum film and the one we've just finished, but he is totally fine now. I spent last Thanksgiving with his family in Texas. We're working together again this year. It never affected my friendship with him at all."
The Around The World in 80 Days funnyman, who played a toy soldier in the comedy, was hit in the eye by a giant plastic prop during an action sequence - causing momentary blindness.
The star was so badly hurt that film bosses had to use heavy make-up to cover the bruising for the remainder of the shoot.
Coogan says, "Honestly, on that film, I really thought I might go blind. During filming one day, I was running along - I play a toy soldier - scampering past these giant blades of plastic grass. But, being really old, I got out of breath, so I stopped. And as I bent over to catch my breath, one of these blades of grass went right in my eye.
"It was horrific - it pushed my eyelid over the top of my eyeball and down over the other side. I bruised my ruddy eyeball - actually, I nearly blinded myself. I stopped and put my hand over my eye - I thought I'd have blood gushing out - I couldn't see anything. My head went numb. I had a black eye for the whole of the rest of the film. They had to cover it up with make-up every day."