Host Black, Klum, Carrey, Snoop Dogg and the night's Arm Fart Hall of Fame inductee Duhamel, who dressed up as Justin Bieber for his sliming, were all prepared for the messy 'honour' but Brand was caught out when he stepped onstage to present the award for Favorite Voice from an Animated Movie to birthday boy Eddie Murphy.
Favorite Movie Actor Johnny Depp opened the proceedings by squirting the audience with a slime canon and setting off fountains of goo that covered the first few rows at the Galen Center in Los Angeles - and the fans hurled globs of the green stuff back onstage as Brand walked on.
Trying to laugh off getting splattered with the green stuff, Brand said, "This is not in the script. You are all going to juvenile hall. You children are going to prison; you are bad children. Johnny, I wish you'd drowned them."
Host Jack Black opened the show with an impressive dance routine on the orange carpet and then became part of the Black Eyed Peas for a colourful musical performance. The Peas picked up the Favourite Music Group prize.
Carrey closed the show by pretending to float into the event in a balloon - and ended up getting slimed. He then sprayed goo all over Black.
The full list of winners at the Nickelodeon Kids' Choice Awards is:
Favorite Female Singer - Katy Perry
Favorite Male Singer - Justin Bieber
Favorite Song - Baby by Justin Bieber
Favorite Movie - The Karate Kid
Favorite Animated Movie - Despicable Me
Favorite Reality Show - American Idol
Favorite TV Actress - Selena Gomez
Favorite TV Actor - Dylan Sprouse
Favorite Book - Diary of a Wimpy Kid series
Favorite Cartoon - Spongebob Squarepants
Favorite Male Athlete - Shaquille O'Neal
Favorite Female Athlete - Lindsey Vonn
Favorite Video Game - Just Dance 2
Favorite Movie Actor - Johnny Depp
Favorite Movie Actress - Miley Cyrus
Favorite Voice from an Animated Movie - Eddie Murphy (Shrek Forever After)
Favorite Music Group - Black Eyed Peas
Favorite TV Show - iCarly
Big Help Award - Justin Timberlake
The Black Swan actress, Glee star Dianna Agron and Olympic athletes Lindsey Vonn and Carly Patterson are said to be among more than 100 celebrities and public figures who have allegedly had their email accounts illegally accessed, according to TMZ.com.
The website reports officials at the Federal Bureau of Investigation (FBI) are looking into the allegations but have not made any arrests.
The investigation is reportedly linked to the nude pictures of Vanessa Hudgens which were leaked online last week (ends20Mar11).
Heroes star Ali Larter, Cougar Town's Busy Philipps, Scarlett Johansson, Miley Cyrus and Jessica Alba are also among the alleged victims who have reportedly had personal photos and other compromising material taken from their computers and cell phones.
The Mean Girls star filed a $100 million (£66.7 million) suit against chiefs at financial firm E-Trade in March (10) over a commercial which depicts a baby girl called Lindsay as a boyfriend stealer and a "milkaholic".
Her legal team accused advertising bosses of exploiting their client's famous first name and public persona without permission, insisting the use of the name Lindsay is a direct reference to Lohan.
E-Trade bosses filed a motion to have the case dismissed in May (10), claiming there are 250,000 women in the U.S. who share the actress' first name.
But Lohan's attorney Stephanie Ovadia is fighting to proceed with the case, insisting her client is the most famous Lindsay out of a handful of celebrities, including Olympic skier Lindsey Vonn, tennis player Lindsay Davenport and actresses Lindsay Price and Lindsay Wagner.
Ovadia's brief, filed in New York Supreme Court and obtained by the Hollywood Reporter, states: "The issue... is not how many people in the USA are with the name 'Lindsay' or 'Lindsey'. The issue is how many celebrities are with this name 'Lindsay' in the USA, and then (sic) in the context, manner, characterisation, persona... If Defendants take this name, 'Lindsay' in context of a celebrity name (sic) then by Defendants' own admission, there are only a few limited celebrities with this name around, and this number may not be more than four or five...
"The type of a particular role and persona, the role of an alcoholic bimbus woman, that (sic) Defendants were looking for in their said commercial, none of the other celebrity 'Lindsay' as (sic) referred by Defendants... fits into."
Lohan is seeking $100 million (£66 million) in exemplary damages and compensation.
Olympics heroine LINDSEY VONN is set for more TV stardom now the Winter Games in Vancouver, Canada are over - the skier has landed a role on top cop drama LAW & ORDER. Vonn, 25, will play a jury foreman in an upcoming episode.