Pretending to be deeply affected by the actress' cheating scandal, the Old School star hit talk show Conan deeply depressed and began to weep as he explained why he was so low, joking, "I don't know if I could have done something to prevent it."
His upset turned to anger when host Conan O'Brien suggested, "I'm sure it's gonna be fine."
Ferrell raged, "It's not gonna be fine, ever... What they had was so special; you would never know... She is a trampire, that's what she is."
Earlier this week (begs30Jul12), Stewart's producer pal Giovanni Agnelli jumped to the actress' defence amid the fallout following her cheating confessions, and urged critics to stop calling her a "trampire" - a reference to her vampire role in the Twilight franchise.
He tweeted, "If you've ever used the word Trampire you're a mindless pathetic piece of s**t."
Stewart stunned fans and Hollywood insiders last month (Jul12) when she revealed a tabloid story about a fling with director Rupert Sanders was true. It now appears her romance with Robert Pattinson is over after removal vans were spotted outside the Los Angeles home the couple shares.
The Twilight star stunned fans and Hollywood insiders last week (ends27Jul12) when she revealed a tabloid story about a fling with director Rupert Sanders was true.
It now appears her romance with Robert Pattinson is over after removal vans were spotted outside the Los Angeles home the couple shares - and his fans have turned on Stewart.
But Agnelli feels the vitriol aimed at his young friend is over the top, insisting there's no way she slept with married Sanders, as has been suggested by some media outlets.
In a series of tweets on Monday (30Jul12), the producer rants, "I'll say right now what the manipulative media isn't saying... Kristen Stewart did not have any type of sex with Rupert Sanders... The spin that keeps growing on this story is staggering. There was NO on set affair. Stop printing LIES.
"If one of your friends in real life was hurting, and lots of people were being cruel. Wouldn't you ask them to please stop? Honestly?"
And, taking aim at Twilight fans who have dubbed Stewart a 'Trampire' following her indiscretion, he adds, "If you've ever used the word Trampire you're a mindless pathetic piece of s**t."
Agnelli also took a moment to thank fans who have pledged their support to Stewart, revealing she has seen a "twitition" and "support video" and adding, "Thank you."
The drama began when shots of Stewart and Sanders kissing featured on the cover and inside last week's Us Weekly magazine in America.