This attractive blonde started acting at age 12, doing mostly commercials until her first TV acting job on "Spencer" (NBC, 1984-85), a short-lived high school sitcom starring Chad Lowe. After a series of guest spots on TV shows, Locane landed her first film role in "Lost Angels" (1989) with Donald Sutherland. It wasn't until she was cast opposite Johnny Depp in John Waters' "Cry Baby" (1990), however, that Locane's career started picking up steam. After two years of steady work, she was cast as Sandy Louise Harling, a Southern belle amongst the trendy California twentysomethings in Aaron Spelling's "Melrose Place" (Fox). Locane's character, however, didn't fit in with the rest of the show and was replaced after the 13th episode. She went on to appear in films opposite Brendan Fraser as his virginal girlfriend in "School Ties" (1992) and later as a tough-as-nails variation in "Airheads" (1994). Locane was featured as Jessica Lange's daughter in director Tony Richardson's final effort, "Blue Sky" (filmed in 1991; released 1994) and was again in the girlfriend role (this time to Jeremy Davies) in "Going All the Way" (1997).