The actress appeared in three movies in the past 12 months – romantic comedy The Proposal, American football drama The Blind Side and comedy All About Steve.
The films proved to be most popular with theatregoers, with The Blind Side taking $193 million (£120.6 million) to date in North America alone.
Bullock’s popularity put her ahead of actors like Johnny Depp and George Clooney in the annual list by Quigley Publishing Company, which collates various pieces of information from cinema owners across the U.S.
The news tops a stellar year for the actress – she was also recently named Entertainment Weekly magazine’s Entertainer of the Year, beating stars including Lady Gaga and Taylor Swift to the top spot.
The top 10 actors with star power in 2009 is as follows:
1) Sandra Bullock
2) Johnny Depp
3) Matt Damon
4) George Clooney
5) Robert Downey, Jr.
6) Tom Hanks
7) Meryl Streep
8) Brad Pitt
9) Shia LaBeouf
10) Denzel Washington.