Landed a supporting role in "This Means War," an action comedy starring Reese Witherspoon, Chris Pine, and Tom Hardy
Wrote and produced the NBC sitcom "Are You There, Chelsea?" based on on her 2008 bestseller Are You There, Vodka? It's Me, Chelsea; also played title character's sister
Hosted the 2010 MTV Video Music Awards
Served as executive producer on the E! reality series "Pretty Wild"
Renewed contract with E! parent company Comcast Entertainment Group to extend her show "Chelsea Lately" through 2012
Published Are You There, Vodka? It's Me, Chelsea, a collection of humorous essays
Performed with Comedy Central's Hour Stand-Up Comedy Tour across the U.S.
Hosted late-night comedy and talk show "Chelsea Lately" (E!)
Appeared in the Internet based program "In The Motherhood" with Leah Remini and Jenny McCarthy
Became a recurring correspondent on "The Tonight Show with Jay Leno" (NBC)
Headlined the E! Network self-titled sketch show "The Chelsea Handler Show"
Wrote her memoir My Horizontal Life: A Collection of One-Night Stands