The star, who is married to actress Portia de Rossi, claimed the top spot in Out’s annual Power 50 rundown.
Singer Adam Lambert and How I Met Your Mother star Neil Patrick Harris featured in the top ten, claiming fifth and seventh place respectively.
Fashion designers Marc Jacobs and Tom Ford were also high in the rundown – at 11 and 13.
Moviemaker Lee Daniels was at 25, while comedienne Wanda Sykes featured at 36. Jodie Foster was placed 41st and Milk director Gus Van Sant came in at 43.