The Pirates of the Caribbean star, who previously scooped the award in 2003, is still making fans swoon at the age of 46.
Depp now joins an elite list of double winners including Brad Pitt, George Clooney and Richard Gere.
He joins 109 other sexy stars on the list, including actors Simon Baker and Matthew McConaughey, soccer ace David Beckham, and Hollywood stars Patrick Dempsey, Will Smith and Josh Brolin.
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