Duffy brought her musical talents to a variety of films over the course of her Hollywood career. Duffy worked on a variety of projects during her early entertainment career, including "FNMTV" "Saturday Night Live" (NBC, 1975-) and "The Late Show With David Letterman" (CBS, 1993-2015). She also contributed to "Up 'n' Under" (1998). In the early 2000s, Duffy devoted her time to various credits, such as "Fashion Rocks" (CBS, 2008-09), "Katie Couric's All Access Grammy Special" (CBS, 2008-09) and "My Best Friend's Girl" (2008) starring Dane Cook. She also worked on "An Education" with Carey Mulligan (2009). Duffy's music was featured in the Kate Hudson comedy "Bride Wars" (2009) and the comedy "Pirate Radio" (2009) with Philip Seymour Hoffman. In addition to her music, Duffy also appeared on-screen in the Matthew Rhys foreign "Patagonia" (2010). Most recently, Duffy acted in "Legend" (2015) with Tom Hardy.