Co-starred with Cher and Christina Aguilera in "Burlesque"
Played a closeted football player in the Garry Marshall's "Valentine's Day"
Joined Jennifer Aniston and Owen Wilson in "Marley & Me"
Cast as Jamie Madrox the Multiple Man in "X-Men 3: The Last Stand"
First leading role in a feature, "Open Water 2"
Joined the cast of ABC's medical drama, "Grey's Anatomy" in the recurring role of Dr. Mark Sloan; became a regular cast member in the third season (2006)
Portrayed a member of the Manson clan in the TV-movie "Helter Skelter" (CBS)
Had a recurring role on "Charmed (WB) as Phoebe Halliwell's boyfriend Jason Dean
Co-starred on the ABC medical drama "Gideon's Crossing"
Made television debut on "The Wonder Years" (ABC)
First major film appearance in the WWI drama, "The Basket"
Played bit parts on the TV series "Married with Children" (Fox) and "Roseanne" (ABC)
In August 2010, Dane and his wife Rebecca Gayheart won a legal battle against Gawker.com, claiming the web site last year unlawfully posted footage and "maliciously" distributed a raunchy homemade video that featured the couple indulging in a threesome with former Miss Teen USA Kari Ann Peniche. Gawker agreed to take down the video and pay an undisclosed sum to the couple in exchange for no further legal action.