Circle in the Square Theatre School
New York University
Interlochen Arts Academy
Royal Academy of Dramatic Art
American Academy of Dramatic Arts
Joined the cast of the series "American Crime"
Co-starred in the comedy-drama "Trust Me"
Played the title character's mother in "Phoebe in Wonderland"
Received a star on the Hollywood Walk of Fame
Played Lindsay Lohan's mother in the Garry Marshall directed, "Georgia Rule"
Portrayed a transsexual woman who discovers that she fathered a child in her former life as a man in the indie drama, "Transamerica"; earned Oscar and SAG nominations for Best Actress
Cast as Lynette Scavo, the ex-career woman and mother of four unmanageable kids in the ABC drama, "Desperate Housewives"; earned Golden Globe (2005, 2006, 2007), SAG (2007) and Emmy (2007) nominations for Best Actress in a Comedy Series
Appeared with husband William H. Macy in the CBS miniseries, "Reversible Errors"
Guest starred as Frasier's Love interest on the NBC comedy, "Frasier"
Co-starred with Eric Stoltz, as a married couple and screenwriting partners, in the Showtime series, "Out of Order"
Portrayed Lady Bird Johnson in HBO movie, "Path to War"
Played a photographer who is charged with child pornography in the Lifetime movie, "Snap Decision"
Appeared with husband William H. Macy (who also co-wrote the teleplay) in the TNT original, "A Slight Case of Murder"
Played small role in "Magnolia" as a TV game show coordinator; husband had more substantial role in the film
Co-starred in Mamet's "The Spanish Prisoner"
Played TV producer Dana Whitaker on the ABC series, "Sports Night"; earned a Golden Globe (2000) nomination for Best Actress
Directed by future husband William H. Macy in "The Joy of Going Somewhere Definite" at the Atlantic Theater Company
Was featured in the Showtime series "Bedtime"
Directed by Mamet in the Atlantic Theater Company production of J.B. Priestley's "Dangerous Corner"
Acted onstage in Mamet's "The Cryptogram"
Appeared as Ed Asner's daughter in the pilot episodes of ABC's "Thunder Alley"; replaced by Diane Venora when the series began
First TV movie, "Quicksand: No Escape" (USA network)
Made TV debut in the Stephen King miniseries, "Golden Years" (CBS)
Featured as one of Dershowitz's Student Staff in "Reversal of Fortune"
Understudied and eventually replaced Madonna in Mamet's Broadway play, "Speed-the-Plow"
Made feature acting debut in David Mamet's "Things Changes"
Was a member of the Atlantic Theater Company, co-founded by David Mamet and William H. Macy
In 2005, Huffman revealed that she had suffered from both anorexia and bulimia in her late teens and twenties.
On Huffman's portrayal of a transsexual: "Your first image of her is so shocking — such a weird, unattractive person," he says. "But by the end of the film, even though the makeup is exactly the same, you've completely fallen for this woman." - Huffman's husband, an executive producer on the film "Transamerica" to USA Today, November 2005