Francis Guinan was widely known for his acting on the big screen. Guinan began his acting career appearing in various films, such as "The Bedroom Window" (1987), the thriller "The Serpent and the Rainbow" (1988) with Bill Pullman and the action picture "Miles From Home" (1988) with Brian Dennehy. He also appeared in the dramedy "Just Like in the Movies" (1990) with Jay O Sanders. He kept working in film throughout the nineties, starring in the action movie "Speed 2: Cruise Control" (1997) with Sandra Bullock and the Ayn Rand adaptation "Ayn Rand: A Sense of Life" (1998). His work around this time also included a part on the TV movie "Spring Awakening" (CBS, 1994-95). He also worked in television during these years, including a part on "Something Wilder" (NBC, 1994-95). Recently, he tackled roles in the action flick "Lansky" (1999) with Richard Dreyfuss, "Guinevere" (1999) with Sarah Polley and the Anthony Hopkins smash hit adaptation sequel "Hannibal" (2001). He also appeared in the Keanu Reeves thrilling adaptation "Constantine" (2005). He also worked in television during these years, including a part on "Grey's Anatomy" (ABC, 2004-). Guinan most recently acted in "Henry Gamble's Birthday Party" (2016) with Pat Healy.