Dedicating her early years to her love of dance, Giovanna Zacarías nevertheless left a position in classical ballet when the opportunity arose to train in acting with renowned Mexican theatrical director Ludwik Margules. The move paid off when Zacarías debuted in the David Mamet play "Sexual Perversity in Chicago". In 2001, Zacarías had a co-starring role in the feature film adaptation of the play "Escrito en el cuerpo de la noche". Just three years later, Zacarías co-starred opposite Scott Glenn and Harvey Keitel in the Hollywood crime drama "Puerto Vallarta Squeeze". Zacarías remained busy with film and television commitments through 2004 and in 2005 won a small but crucial role in another Hollywood feature film, "The Legend of Zorro", starring Antonio Banderas and Catherine Zeta-Jones. After this brief sojourn into the American film industry, Zacarías returned to Mexico and co-starred in the historical drama "Las vueltas del citrillo" set in pre-revolutionary Mexico. Zacarías continued appearing regularly on Mexican television and feature films including the television movie "Cielo" and the series "Capadocia". In 2008, Zacarías moved into a new genre, appearing in the English-Spanish science fiction film "Sleep Dealer", In 2010, she co-starred with Peter Coyote and Elsa Pataky in the romantic drama "Di Di Hollywood".