Co-starred in Kevin Hart/Josh Gad comedy "The Wedding Ringer"
Starred in indie comedy "Authors Anonymous"
Played murder victim Stacy Peterson in Lifetime TV movie "Drew Peterson: Untouchable"
Co-starred in Hank Williams biopic "The Last Ride"
Co-starred in the live-action/CGI film "Hop"
Starred in the Lifetime movie "To Be Fat Like Me"
Played struggling actress Penny on CBS sitcom "The Big Bang Theory"
Joined the eighth season of The WB show "Charmed" as a young witch in training
Voiced the character of Brandy Harrington on the Disney Channel's "Brandy and Mr. Whiskers"
Co-starred in the ABC Family original movie "Crimes of Fashion"
Cast in the NBC miniseries "10.5"
Landed breakthrough role as the eldest daughter of John Ritter's character on the ABC sitcom "8 Simple Rules"
Portrayed Maureen McCormick in the NBC TV-movie "Growing Up Brady"
Cast as Bonnie on the CBS sitcom "Ladies Man"
Had a small role in "Picture Perfect," starring Jennifer Aniston
Made feature film debut in "Virtuosity," starring Denzel Washington and Kelly Lynch
Appeared on an episode of "Northern Exposure" (CBS)
Played a young Angela in "My So-Called Life" (ABC)
Made TV-move debut in "Quicksand: No Escape" (USA Network) with Donald Sutherland and Tim Matheson
Began modeling at age six
Cuoco grew up with fellow actress Ashley Tisdale, who asked Cuoco to be her date to her high school prom.
A devoted equestrian, Cuoco was involved in a serious riding accident on September 13, 2010, crushing several bones in her left leg. She missed two episodes of "The Big Bang Theory" and spent most of the rest of the season hidden behind a bar on the show's restaurant set to hide her cast.
During her brief 2013-15 marriage to tennis player Ryan Sweeting, Cuoco was billed as Kaley Cuoco-Sweeting.