Illinois State University
Voiced the role of Mrs. Davis in "Toy Story 4"
Joined the cast of CBS's "The McCarthys"
Cast on HBO's "Getting On"
Voiced the character of Mrs. Davis in the animated feature "Toy Story 3"
Cast as the downtrodden mother Meg in the off-Broadway revival of Sam Shepard's "A Lie of the Mind"; directed by Ethan Hawke
Appeared in the short-lived Broadway revival of Neil Simon's "Brighton Beach Memoirs"
Cast opposite Nathan Lane in the Broadway production of David Mamet's "November"; received a Tony award nomination for Featured Actress in a Play
Became a recurring character on the sitcom "Big Bang Theory"
Cast in the Garry Marshall-directed dark comedy "Georgia Rule"
Co-starred in the comedy, "Artie Lange's Beer League"
Earned an Emmy nomination for Best Guest Actress in a Comedy Series for "Monk"
Guest starred on ABC's "Desperate Housewives" as meddling neighbor Carolyn Bigsby; earned an Emmy nomination for Outstanding Guest Actress in a Comedy Series
Replaced Julie Walters in the London stage production of "All My Sons"
Cast as a psychiatrist in Mike Figgis' experimental "Time Code"; not seen in theatrically released version; replaced by Glenne Headley; will be included on the DVD release
Starred in the L.A. premiere of "Looking for Normal"
Starred opposite Norm Macdonald in ABC's "Norm/The Norm Show"
Had pivotal role in "Scream 2"
Broadway debut, "My Thing of Love"
Played the title character's younger sister, Jackie on the ABC sitcom "Roseanne"; earned Emmy (1995) and Golden Globe (1993, 1995) nominations for Best Supporting Actress
TV movie debut, "The Execution of Raymond Graham"
Feature film debut, "Desperately Seeking Susan"
Went to New York with Steppenwolf production of "Balm in Gilead"
Cast member of TV series, "Saturday Night Live"
Was raised in Edwardsville, Illinois.
Began her professional acting career at Chicago's legendary Steppenwolf Theatre in the '70s alongside John Malkovich and Gary Sinise.