The 62-year-old has played seductress Erica Kane in the soap opera for nearly 40 years and is now uprooting her life for the series.
Lucci will move West when the show leaves its longtime New York studios and begins production across the country early next year (10).
Her co-stars Thorsten Kaye and Ray MacDonnell, who has starred as Dr. Joe Martin in the series since its inception, have retired from the show and will not be making the cross-country move.
All My Children will tape its last episode in New York on 11 December (09). Production will resume in Los Angeles on 4 January (10).