The show, starring Robert Vaughn and David McCallum as secret agents, enjoyed a successful run between 1964 and 1968.
The series was so popular it spawned a series of spin-off movies, which saw several episodes extended and shown in movie theatres as full-length features.
Vaughn and McCallum returned to the roles in 1983 for a TV movie, titled The Return Of The Man From U.N.C.L.E.
And now executives at film studio Warner Bros have announced they are moving forward with plans for a new movie, based on the hit 1960s show, with the appointment of Wedding Crashers director David Dobkin and scriptwriter Max Borenstein, according to the Hollywood Reporter.
It is believed the picture will feature a new cast, and will follow in the footsteps of other big screen remakes such as Miami Vice and The A-Team.