Simon Helberg made a career out of playing loveable nerds, but always with a twist. He honed his skills on the long-running sketch comedy series "MADtv" (Fox, 1995-2009) and on the fictional show-within-a-show "Studio 60 on the Sunset Trip" (NBC, 2006-07), where he did impressions of more experienced comics like Ben Stiller and Jimmy Fallon. But it was his turn as the bowl-cut physics nerd, Howard Wolowitz, on "The Big Bang Theory" (CBS, 2007- ) that made Helberg star. His overly confident character fancied himself a ladies' man, and sported a look that the actor reportedly once described as "Jewish mod," super-tight pants, bright turtlenecks and Vans shoes. The series steadily gained mass appeal, as did Helberg, whose wacky antics, mental flexing, and hilarious attempts to land a girlfriend gave Hollywood plenty of reasons to expect a long and successful career out of the talented comedian.