After the Zanuck/Brown partnership ended in 1988, the husband and wife team formed The Zanuck Company, whose first film, the relatively low-budget "Driving Miss Daisy" (1989), directed by Bruce Beresford, won four Oscars, including Best Picture. Since then, she has co-produced such films as "Rich in Love" (1993), Walter Hill's "Wild Bill" (1995) and "Mulholland Falls" (1996).
Zanuck made her small screen debut co-producing the TV-movie "Barrington" (CBS, 1987). Her successful directorial debut was the tautly-paced "Rush" (1991), a relentlessly grim account of idealistic undercover narcotics officers who sink into drug use in order to effectively make a case. While the film featured strong performances from its leads Jennifer Jason Leigh and Jason Patric, its downbeat subject matter kept audiences at bay. In 1997, Zanuck was one of the directors chosen (along with Tom Hanks and Ted Demme, among others) to helm segments of the HBO anthology "From the Earth to the Moon".