Mitra was then tapped for roles in “Hollow Man” (2000) with Kevin Bacon and Elizabeth Shue and then worked with Sylvester Stallone on “Get Carter” (2000). Mitra spent one year playing a doctor on the ill-fated but critically acclaimed “Giddeon’s Crossing” (ABC 2000-2001). After playing a role on the wacky British film “Ali G Indahouse” (2002)--as a scheming vixen who is oddly beguiled by Sasha Baron Cohen’s clueless cult favorite character—Mitra got another break that same year with an appearance in the Reese Witherspoon vehicle “Sweet Home Alabama.” In 2003, she starred in “Highwaymen” with Jim Caviezel and appeared in “The Life of David Gale” (2003), starring Kate Winslet and Kevin Spacey.
Mitra made a cameo in 2003’s “Stuck on You” with Greg Kinnear and Matt Damon as the Bus Stop Bombshell, before beginning the legal epoch of her career, beginning with her turn as the sultry attorney Tara Wilson on the final season of “The Practice” and was able to star in “Spartacus” (2004) with Alan Bates, before her character was carried over to “Boston Legal” opposite James Spader and the inimitable William Shatner (ABC, 2004 - ). The character was axed for a second season retooling, but Mitra immediately found a new home of the edgy FX series "Nip/Tuck" in 2005, playing Tara Wilson, an emotionally scared federal investigator tracking the serial killer The Craver who becomes sexually involved with one of the victims, Christian Troy (Julian McMahon) and his paramour Kimber (Kelly Carlson)