T.R. Knight

With his hangdog eyes and nerdy appeal, Knight instantly charmed viewers as a lovesick doctor on the wildly popular medical drama Grey's Anatomy. Prior to landing his seminal role, he was primarily a stage actor, honing his craft at the prestigious Guthrie Theater in his hometown of Minneapolis before moving to Broadway. Although he only had a handful of TV guest spots under his belt when he was cast on Grey's, he became one of the breakout stars of the breakout hit. In October 2006, he publicly acknowledged that he was gay, dashing the crushes of countless female fans. His annoucement came a few days after his Grey's costar, Isaiah Washington, allegedly made a homophobic remark. Although the incident seemed to fade away, Washington stirred up bad blood again in January 2007 when he claimed that he hadn't called Knight "a f-gg-t" during a post-Golden Globes press conference. Washington later retracted his denial but was subsequently fired at the end of the hit show's third season.