Rue made her regular series debut in 1990 on the serial NBC sitcom "Grand" portraying the well-adjusted and self-possessed daughter of a single mother (Pamela Reed). In 1992 she returned to the big screen, playing one of the grandchildren of the deceased in the comedy-drama "Passed Away". That same year she had a memorable guest role on the ABC sitcom "Roseanne", cast as a teenage incarnation of the title character in an "A Christmas Carol"-reminiscent Halloween special. A recurring role on the sitcom "Phenom" kept her with ABC from 1993-1994, and in 1995 she was featured in the network's TV-movie comedy "Family Reunion: A Relative Nightmare".
Regular series called again, and Rue was cast as the endearingly spacey receptionist for a child psychologist (Rondell Sheridan) on the sitcom "Minor Adjustments" (NBC, 1995; UPN, 1996). The actress stayed in the public eye with roles in the TV-movies "For My Daughter's Honor" (CBS, 1996) and "Silent Hearts" (Lifetime, 1998), but series work would offer her greater opportunity to create memorable characters. In 1998, she guested on an episode of CBS' medical drama "Chicago Hope", playing a troubled pregnant teen handcuffed by court order to her exceptionally abrasive mother. She was also featured in a recurring capacity on the forgettable Martha Stewart-spoofing CBS sitcom "The Simple Life" (1998). The following year she made an impression in the snarky sitcom "Zoe, Duncan, Jack & Jane" (The WB) playing Breeny Kennedy, a brutally cunning wheelchair-bound bully. Rue's theatrical take on this unexpected and over-the-top villain helped inject the show with added punch, but didn't raise the low ratings. More successful was her turn as wannabe cheerleader Carmen Ferrara on "Popular", which won the actress many fans and admirers. The series, in turns realistic and fantastical, offered Rue the opportunity to develop a multifaceted and compelling yet altogether human characterization that helped to fight single-minded stereotypes about women based on size while allowing the actress to hone her dramatic and comedic skills.
On the big screen, Rue went from stealing scenes as the ranting activist Earth Girl in the teen comedy "Can't Hardly Wait" (1998) to holding her own in the effecting dramas "A Slipping Down Life" and "A Map of the World", starring alongside Lili Taylor and Sigourney Weaver respectively. Although she would be featured as a nurse in the 2001 summer blockbuster "Pearl Harbor", that year's "Gypsy 83" would finally allow the actress her starring feature debut, playing a young woman who idolizes iconic and eccentric rock singer Stevie Nicks. In 2002, Rue was cast as Claude, a newbie in the world of corporate ladder climbing, in the the ABC sitcom "Less Than Perfect." Rue gelled well with her co-stars and provided a strong audience surrogate on the show, prompting its renewel after delivering moderate ratings.