Miller began to land acting jobs, like the 1992 HBO movie "Stepfather III", episodes of NBC's hit "Seinfeld", and a minor role in the TV-movie "A Friend to Die For" (NBC, 1994). In 1999, she had major supporting roles in the independent films "The Operator" (as the long-suffering wife of sleazy lawyer) and "Smiling Fish and Goat on Fire" (as a post office employee involved with an aspiring actor).
Miller married sit-com writer-producer Bill Lawrence, the co-creator of "Spin City," in 1999 and eventually left the security of her cozy "Drew Carey" gig in 2002 after Lawrence created a recurring role for her in his latest hit series, the hospital sit-com "Scrubs" (NBC, 2001- ). After primarily providing straight lines and supportive girlfriend shtick on her previous series, Miller was allowed to adroitly break type as the acid-tounged harridan Jordan Sullivan, the former wife of Dr. Cox (series regular John C. McGinley) and a hospital board member who takes pleasure in disrupting the lives of the staff.