Derricks made his feature debut in a small role in "Fort Apache, The Bronx" (1981) but won his first kudos with his meaty role in "Moscow on the Hudson" (1984), as a security guard who befriends Russian emigre Robin Williams. His next two features were less well-received on the whole, but Derricks won favorable notices as one of Michael O'Keefe's baseball colleagues in "The Slugger's Wife" (1985) and almost the only praise that the notably unfunny comedy "Off Beat" (1986) garnered.
Derricks subsequently left features and has dedicated most of his energies over the past decade to TV work. After acting in a number of comedy and drama pilots he won his first series role in "Good Sports" (CBS, 1991), as part of the sport newsroom team headed by Farrah Fawcett and Ryan O'Neal. He followed up as one of the handful of post-apocalyptic survivors in the outlandish "Woops!" (Fox, 1992) and as the party and sports-loving Uncle Charles on "Thea" (ABC, 1993-94). Derricks did his professional best by these short-lived series, and enjoyed at least some measure of better luck with his first show to be renewed for a second season, "Sliders" (Fox, 1995-97; Sci-Fi Channel 1998- ). A mid-season replacement hoping to cash in on the popular trend for sci-fi sparked by "The X-Files" and various "Star Trek" series, "Sliders" featured Derricks as Rembrandt 'Crying Man' Brown, part of an R&B singing group, who accidentally gets caught up in a time-traveling vortex each week.