Doyle-Murray was a writer and sporadic performer during the halcyon days of "Saturday Night Live". He co-wrote the popular "slobs vs. snobs" comedy, "Caddyshack" (1980) with director Harold Ramis and Douglas Kenney. Doyle-Murray also acted in the film, as he would in a number of features associated with the SNL/SCTV/National Lampoon confederation including "National Lampoon's Vacation" (1983), "Sixteen Candles" (1984), Bill Murray's dramatic vehicle, "Razor's Edge" (1984), "Wayne's World" (1992) and "Groundhog Day" (1993). In a marked change of pace, Doyle-Murray played Jack Ruby in Oliver Stone's "J.F.K." (1991).
In recent years, Doyle-Murray has established himself as supporting actor in TV sitcoms. He was quietly charismatic as John "Mac" McKinney, the righthand man of a Nixonian cable mogul on "Good Sports" (CBS, 1991). Doyle-Murray was amusingly cranky as Chris Elliot's landlord during the second season of "Get a Life!" (Fox, 1991-92). He was surprisingly dignified as a veteran cop on "Bakersfield P. D." (Fox, 1993-94) a superior police spoof.