After gaining experience in San Francisco's Little Theater and Asian-American theater scenes, Wong acted in New York in the David Henry Hwang plays "Family Devotions" and "Sound and Beauty". He also understudied on Broadway for David Hare's "Plenty" and did a TV stint on "Search for Tomorrow". Wong's film breakthrough came with his Uncle Tam in Wayne Wang's low-key "Dim Sum: A Little Bit of Heart" (1985) and he was suddenly much in demand in features.
Some of Wong's best roles came in later Wang films: in the comedy "Eat a Bowl of Tea" (1989) he amusingly played a New York gambling club owner who goes after his cuckold son's rival with a meat ax. He appeared in "Life Is Cheap...But Toilet Paper Is Expensive" (1989) as the blind man, and in "The Joy Luck Club" (1993) as Old Chong. The latter role typified many of Wong's more standardized roles, as with his wise man in the strange Eddie Murphy vehicle, "The Golden Child" (1986) and the grandfather of "3 Ninjas" (1992) and its sequels. "The Last Emperor" (1987), though, enabled Wong to recreate part of Chinese history, as did the TV-movie "Forbidden Nights" (1990), set during the Cultural Revolution, and the PBS "American Playhouse" drama, "Paper Angels" (1986), which explored the treatment of Chinese immigrants to America.
Wong has also been billed as 'Victor K. Wong'; he is not to be confused with Los Angeles-born character actor Victor Wong (born September 24, 1906; died April 7, 1972), whose credits included "Son of Kong" (1933) and "Without Regret" (1935).