After "Cheers" put him on the map, Wendt started getting larger movie roles. He followed supporting turns in "Dreamscape" (1984) and "Fletch" (1985) with a memorable portrayal of Buster, a welder at the auto plant who finds himself chafing under the new Japanese regime, in Ron Howard's "Gung Ho" (1986). Co-starring with Robert De Niro and Annette Bening in veteran producer Irwin Winkler's writing and directing debut, "Guilty By Suspicion" (1991), Wendt offered a strong, solid turn as a screenwriter struggling with the issue of whether or not to name names when called before the House Committee on Un-American Activities. Although he has appeared in subsequent movies like "Forever Young" (1992), "The Man of the House" (1995) and "The LoveMaster" (1997), Wendt has remained best known for his small screen performances.
Anxious to capitalize on his extreme popularity from "Cheers", CBS launched "The George Wendt Show" (1995), which disappeared quickly, possibly because its format (Wendt as a radio call-in show host) was shamelessly similar to fellow "Cheers" alum Kelsey Grammer's "Frasier". NBC penciled him in as a newspaper editor in its revamp of the sitcom "The Naked Truth" (1997) but almost as quickly rubbed him out when the show's concept was again changed. He starred in the Fox movie "Hostage For a Day" (1994) as a man who stages his own abduction to get away from his overbearing wife and miserable job and portrayed Mr. MacAfee in the 1995 ABC remake of the musical "Bye Bye Birdie". Wendt has co-starred as one of the title characters in "Roger Corman Presents Alien Avengers" (Showtime, 1996) and its sequel "Alien Avengers II" (The Movie Channel, 1997). His performance as of the owner of a firm that sells funeral insurance in "The Price of Heaven" (CBS, 1997), directed by Peter Bogdanovich, garnered him critical praise and invoked comparisons to Orson Welles and Burl Ives.