Prentiss resumed her film career as Elliot Gould's wife in the dismal "Move" (1970). She fared better as the sexy Nurse Duckett in "Catch-22" (also 1970), directed by Mike Nichols. In "The Parallax View" (1974), Prentiss shone in the brief role of a TV reporter who feared for her life after witnessing a political assassination. The following year, her natural, down-to-earth style was most apparent when she uttered her introductory line concerning her family's last name being "Marco. That's upward mobility for Markowitz" in "The Stepford Wives" (1975).
Prentiss curtailed her schedule for much of the late 70s into the early 90s to concentrate on child-rearing, although she accepted the occasional juicy role. In "The Black Marble" (1980), she was a cop romantically involved with her partner, played Jack Lemmon's wife in Billy Wilder's last feature "Buddy, Buddy" (1981) and acted opposite Benjamin in the horror spoof "Saturday the 14th" (1981). Her small screen credits include the TV-movies "Packin' It In" (CBS, 1983) and "M.A.D.D.: Mothers Against Drunk Driving" (NBC, 1983). With her children grown and in college, she began to resume her career in earnest with guest appearances on "Murder, She Wrote" and "Burke's Law", an uncredited bit as a nasty nurse in the Benjamin-directed "Mrs. Winterbourne" (1996) and an L.A. stage role as a dying woman in "Angel's Share" in 1997.