On television, Sperber costarred in the ABC sitcom "Bosom Buddies (1980-82) in which Tom Hanks and Peter Scolari played two men who dressed as women in order to rent an apartment in an girls-only building; Sperber played their neighbor Amy--the only one with insider knowledge of their charade. Sperber's character was hopelessly in love with Scolari's character. She later appeared in Hanks' 1984 big-screen comedy "Bachelor Party," an early stop during his ascent to film superstardom.
Sperber's enjoyed steady supporting and character work, including a stint on the television version of the film "Private Benjamin" (1981) and finally a lead in the 1990 Fox sitcom "Babes," about three not-thin sisters. The show lasted just one season, and she had a season long stint on the John Ritter-Markie Post sitcom "Hearts Afire" in 1992-1993. Even after she was diagnosed with cancer in 1997, Sperber continued to amass credits--from a 1998 episode of "Murphy Brown" dealing with its title character's own chemotherapy woes, to a role as a college professor in the comedy "Sorority Boys" (2002) to a recurring role on Ritter's 2002-05 ABC sitcom "8 Simple Rules." Sperber founded a cancer support center, weSPARK, in 2001 in Sherman Oaks, California--"SPARK" stands for "Support, Prevention, Acceptance, Recovery and Knowledge." She lost her eight-year battle with cancer at age 46 in 2005.