A founding member of Chicago's celebrated Second City Players in 1960, Harris came with them to appear in "From Second City" on the NY stage. Moving to NYC she established a positive reputation on and off-Broadway before alternating between stage and screen. Harris racked up three Tony nominations, including one for her delightful turn as the daffy heroine of "On a Clear Day You Can See Forever" (1966). She won the 1967 Best Actress in a Musical Play Tony for "The Apple Tree", in which she played multiple roles opposite Alan Alda and Larry Blyden. Two of her most noteworthy feature credits were in memorable 70s films from divergent auteurs Robert Altman and Alfred Hitchcock: in "Nashville" (1975), Harris was Albuquerque, a housewife whose dream of becoming a country-Western singing star seemingly comes true after an unexpected tragedy; in "Family Plot" (1976), she was a phony but basically benign psychic. Hollywood was less kind for the remainder of the decade.
Harris struggled gamely in the Disney comedies "Freaky Friday" (1976) and "The North Avenue Irregulars" (1979) and won some excellent notices as the frustrated wife of a senator (Alan Alda) in "The Seduction of Joe Tynan" (1979) but by then her star had decisively fallen.
Harris all but disappeared in the 80s, surfacing briefly in Hal Ashby's disastrous "Second-Hand Hearts" (1980), where even her performance was savaged by reviewers; a bit as Kathleen Turner's mom in Francis Coppola's time-traveling "Peggy Sue Got Married" (1986); and a small part as a wealthy traveler conned by a scheming Michael Caine in the comedy "Dirty Rotten Scoundrels" (1988). Harris should not be confused with the young character actor of 80s film and TV with the same name.