Soon thereafter, though, Vance began a memorable theater association with playwright-director George Wolfe, winning awards for his anthology piece examining African-American stereotypes, "The Colored Museum" (1986), as well as for the later "Spunk" (1991), based on short stories by Zora Neale Hurston. She also began a feature film career in the late 1980s and, after playing small roles in films including "Sticky Fingers" (1988) and "The War of the Roses" (1989), began to make some headway with her first leading role in "Jumpin' at the Boneyard" (1991). Unfortunately, Vance also had to contend with breast cancer, which was diagnosed in 1990. She had a mastectomy and even created a performance piece, "The Radical Girl's Guide to Radical Mastectomy", which premiered at New York's Public Theater in the 1991-92 season, but a recurrence of the disease in 1993 would finally prove fatal, robbing the theater scene of a distinctive and versatile comic presence at age 35.