On the big screen, Lee had leads in Disney's slapstick fantasy "The Love Bug" (1969), about a Volkswagen with a mind of its own, and "The Comic" (1969), an uneven serio-comedy about a destructive comedian co-starring Dick Van Dyke and Mickey Rooney. In the late 1970s, Lee landed a regular role on the CBS nighttime soap opera "Knots Landing" playing Karen MacKenzie and appeared in every episode until the series folded at the end of the 1992-1993 season.
Lee has guested or starred on numerous TV variety shows and has made dramatic appearances in several TV-movies. She has also maintained a busy singing career appearing in nightclubs around the country and cutting a number of singles and albums for Columbia Records. Lee directed episodes of "Knots Landing" during the show's final seasons. She co-wrote, executive produced, directed and starred in the 1996 Lifetime telefilm "Color Me Perfect".