On the small screen, the actress has lent her unique talents to a variety of memorable roles. Zabriskie was effective as a snake-handler who attempts to romance a detective in a two-part 1986 installment of NBC's "Hill Street Blues" and as the supportive wife of Admiral Elmo Zumwalt in the CBS biopic "My Father, My Son" (1988). Zabriskie went on to play the grandmother of a child stricken with AIDS in "The Ryan White Story" (ABC, 1989), and the therapist of a sexually abused teen in "A Deadly Silence" (ABC, 1989). The following year, David Lynch tapped her to portray the excessively sobbing mother of murder victim Laura Palmer in the quirky primetime serial "Twin Peaks" (ABC), which she reprised in the confusing 1993 feature prequel "Twin Peaks: Fire Walk With Me". Zabriskie had the recurring role of the mother of Susan Ross, George Costanza's ill-fated fiancee in several episodes of "Seinfeld". She also offered an effective supporting turn as Jennifer Jason Leigh's mother in the controversial but critically-praised "Bastard Out of Carolina" (Showtime, 1996). She also had a recurring stint as Yellow Teeth on the sci-fi series "John Doe" (UPN, 2002-2003) and appeared as The Crone on the popular WB witchcraft-lite series "Charmed."