Melissa George was born in Perth, Australia, on Aug. 6, 1976. Her’s was an unusual path to show business, with childhood dance lessons leading to a sports career on the competitive roller-skating circuit, where she became a national champion. That exposure led to the fresh-faced teen being “discovered” for modeling work, and after snagging the title of Western Australia’s Teenage Model of the Year at age 16, she was cast on the popular nighttime soap "Home and Away." George quickly became a fan favorite with her portrayal of runaway Angel, and during the course of her three-year run on the show, her character went from disheveled new girl in town to the center of the series – a teen single mother who became half of the series power couple, loses her mate, has his child and is finally swept away by a dashing young millionaire for her 1996 exit from the series. A favorite star in her native land, George released a line of sleepwear, An Angel at My Bedside, and starred in a teen-aimed health and fitness video "Mind, Body & Soul." In a 1997 effort to put her teenage image behind her, the 21-year-old bared her enviable shape in Australian Playboy in 1997, and the seemingly controversial move did not have much of a detrimental effect on her fan base, but rather, kept her in the public's mind.
A recurring role on the U.S./Australian co-production "Roar" (Fox, 1997) marked George’s introduction to American audiences. She appeared opposite fellow Aussie up-and-comer Heath Ledger in the medieval-set adventure, where her long dark hair and revealing costumes had audiences likening her to the similarly-themed "Xena, Warrior Princess" (Syndicated, 1995-2001). When "Roar" failed to make the leap to a second season, the undaunted actress set up a permanent home in Los Angeles in hopes of building a new career. The following year, she made her feature film debut with a small but pivotal role in the critically praised sci-fi noir "Dark City" (1998). In Stephen Soderbergh’s similarly dark revenge drama "The Limey" (1999), she had a supporting role as a doomed young woman whose ex-con father (Terrence Stamp) goes on a mission to avenge her death.
While still relatively unknown in the United States, George’s summer of 2000 wedding to Chilean film director Claudio Dabed in Bali was invaded by paparazzi-filled helicopters scooping the event for George’s fan base in Australia and the United Kingdom. She did begin to make headway with mainstream American audiences the following year as a cheeky high-school cheerleader and bank robber obsessed with "Late Night" host Conan O'Brien in the teen black comedy, "Sugar & Spice" (2001). She had a small role in David Lynch’s dizzying but critically adored tale of aspiring Hollywood actresses, "Mulholland Drive" (2001), and landed alongside John Stamos in the short-lived but memorably sexy primetime adventure series "Thieves" (ABC, 2001), playing a tech-savvy career criminal. After several more false starts in ill-fated series pilots, George’s career was boosted with a recurring appearance as the too-sexy nanny to Ross and Rachel's daughter on "Friends" (NBC, 1994-2004) and a prominent guest spot on "Charmed" (WB, 1998-2006).
In 2003, George joined the cast of the wildly popular action-adventure series "Alias" (ABC, 2001-06) in its third season in a villainous recurring role as NSC Liaison Lauren Reed, who married Sydney’s (Jennifer Garner) former beau (Michael Vartan) while the spy was in a coma. She finally landed a significant big screen success with the 2005 remake of the supernatural classic “The Amityville Horror,” playing the mother of a family whose home is possessed by evil spirits. Her star continued to rise with a strong supporting role in the noir thriller “Derailed” (2005), in which she played the schoolteacher wife of a Chicago ad executive (Clive Owen), whose affair with a vibrant woman (Jennifer Aniston) leads to a pitfall of crime and deception. “Turistas,” a low-budget thriller about a group of backpackers stranded in the remote Brazilian jungle after a tour bus accident, was released on home DVD the same year.
George stayed on the horror/thriller track for her next spate of film offerings, playing a detective investigating a rash of murders in “W?Z” (2007), and a small-town Alaska resident under siege by vampires in the moderately successful “30 Days of Night” (2007), starring Josh Hartnett. In a refreshing change of pace, George co-starred alongside Michael Sheen and Ron Livingston in the inspirational indie “Music Within”(2007), about a handicapped Vietnam vet who worked to change America’s perceptions about the disabled. In 2008, George landed her highest profile role to date when she was cast in a recurring role on top-rated medical drama “Grey’s Anatomy” as a bisexual surgical intern who stirs up the hospital’s romantic storylines. Concurrently, she was cast in a regular role in the Emmy-winning HBO drama “In Treatment” (HBO, 2008-) as a psychotherapy patient who is, herself, a medical anesthesiologist. Despite not being picked up to continue her role in the show’s second season, George earned a Best Supporting Actress Golden Globe nomination for her “In Treatment” work in season one. George also found time to make a brief return to Australia in 2009 to shoot the ocean-bound thriller feature, “Triangle” (2009).