Comden and Green segued to the big screen with their screenplay for the remake of the 20s hit "Good News" (1947). The pair also wrote the witty musical "The Barkleys of Broadway" (1949), which brought Fred Astaire and Ginger Rogers together after ten years. The same year, they provide lyrics for the Gene Kelly vehicle "Take Me Out to the Ballgame". In 1952, they provided the brilliant structure for what many consider to be the greatest movie musical, "Singin' in the Rain". The following year, Comden and Green adapted the stage musical "The Band Wagon" and provided Astaire with one of his best screen roles. The duo adapted their own "Bells Are Ringing" (1960) and wrote the non-musical screenplay for "Auntie Mame" (1958).

Comden has sporadically worked as a performer. On stage, she was featured in "On the Town" and she and Green won kudos for their revue "A Party With Betty Comden and Adolph Green" (first performed in 1957), a collection of sketches and songs. Comden turned in a fine comic portrayal of a Jewish mother in Wendy Wasserstein's off-Broadway hit, "Isn't It Romantic" (1984- 85). On film, the petite, dark-haired, throaty-voiced Comden was featured in "Greenwich Village" (1944), played the reclusive screen legend in "Garbo Talks" (1984) and appeared in James Ivory's "Slaves of New York" (1989).