With Richard Kobritz, Hurd produced the futuristic parable "Alien Nation" (1988), a revolutionary film melding the buddy-cop and sci-fi genres with a touch of social issues thrown in. (She later was a creative consultant on the 1989-90 Fox series it inspired.) She also executive produced the cult favorite "Tremors", about giant wormlike creatures, and "Downtowners" (both 1990), a relatively unsuccessful return to the buddy-cop formula. In partnership with HBO Pictures, she oversaw the intriguing if not completely successful "Cast a Deadly Spell" which premiered on the cable network in 1991 and was directed by Martin Campbell. Hurd undertook identical responsibilities for the off-beat, critically-praised "The Waterdance" (1992), Neil Jimenez's bravely funny and poignant semi-autobiographical drama about a group of men adjusting to their physical handicaps. In recognition of her commitment to independent filmmaking, the Independent Feature Project/West asked her to serve on the organization's board of directors.

Enduring a stormy brief second marriage to Brian De Palma that resulted in the thriller "Raising Cain" (1992), Hurd went on to oversee a variety of features that met with mixed results at the box office, despite their artistic quality. "No Escape" (1994), helmed by Martin Campbell, was pure entertainment, a futuristic action adventure featuring Ray Liotta as a man attempting to bust out of a maximum security prison. "Witch Hunt" (HBO, 1994), directed by Paul Schrader, was a supernatural comedy that attempted to draw parallels between McCarthyism and witchcraft and served as a sequel of sorts to "Cast a Deadly Spell". Hurd produced the big screen family drama "Safe Passage" (1994) which became more noted for the legal wranglings instituted by an alleged collaborator (whose claims were finally dismissed in the courts) than for the well-acted though mawkish storyline about a woman (Susan Sarandon) coping with the news that one of her sons may have been killed. Hurd arguably enjoyed her biggest success in the mid-90s with the HBO biopic "Sugartime" (1995), which examined the alleged relationship between singer Phyllis McGuire and reputed mobster Sam Giancana. (McGuire vociferously objected to the depiction of the relationship in the movie, but the film featured strong performance by Mary-Louise Parker and John Turturro in the leads). "The Ghost and the Darkness" (1996) proved to be a rousing, old-fashioned period drama about lions that were attacking a building site in Africa while "The Relic" (1997) was a thriller about a mysterious museum piece. Brought in too late to salvage "Dante's Peak" (1997), which also suffered from being the second film about a volcano eruption that year. Hurd demonstrated her skill and creativity for producing a large-scale film with the megahit "Armageddon" (1998), a summertime extravaganza co-scripted and executive produced by third husband Jonathan Hensleigh in which Bruce Willis and company save the world from an oncoming asteroid. (It was the first under her production banner Valhalla Motion Pictures.) On the other hand, "Virus" (1999), a cross between "Alien" and 1995's "Outbreak" fizzled at the box office.

Hurd next served as producer on the summer sci-fi comedy "Clockstoppers" (2001) and had several other projects in the pipeline, including two highly-anticipated features: the as yet untitled second sequel to "The Terminator" with Arnold Schwarzennegger once again in the title role; and "The Hulk", Ang Lee's projected take on the popular comic book "The Incredible Hulk".