Gleason's film roles, though few and small, have been notable, especially as the embarrassed wife of Woody Allen and Mia Farrow's prospective sperm-donor (Tony Roberts) in Allen's "Hannah and Her Sisters" (1986) and as Woody Allen's indifferent wife in "Crimes and Misdemeanors" (1989). She also had a brief but memorable turn as Mark Wahlberg's unhappy mother in "Boogie Nights" (1997). Gleason's first break on the small screen was in a regular role on the sitcom "Hello, Larry" (NBC, 1979-81), about a radio show host who gives on-air romantic advice. She went on to appear in several specials, including recreating her role from "Into the Woods" for PBS' "American Playhouse" series in 1991. Gleason landed a regular role on the CBS sitcom "Love & War" (1992-95), as Nadine Berkus, a waitress wannabe who has fled her suburban housewife existence and jailbird husband to make a life of her own. With pretensions to upgrading the restaurant, she brought a daffy elegance to a character who seemed perpetually on the make. She returned to series TV with a 1996 recurring role as a love interest of Dr. Mark Greene (Anthony Edwards) on the hit NBC drama "ER".